Meeting  Abstracts for Chris Southan

 

Total 50.  presenting author on 30 posters,  co-author on 19.  This is a non-overlapping set i.e. any  meeting abstracts  which were associated with an oral presentation,  a journal paper or a book article from the meeting  are only cited once in the publications or presentations lists and are therefore not  included below.

 

[50] Southan C, Lyall A and Cameron G. (2009) The ELIXIR Database Provider Survey

Intelligent Systems for Molecular Biology (ISMB) 2009 July 2009, Stockholm, Sweden [slideshare]

 

[49] Southan C and Hancock J M. (2009) The evolution of beta amyloid cleaving enzyme (BACE1): an Alzheimer’s Disease drug target. Biochemical Society / Wellcome Trust Focused Meeting  Protein evolution: sequences, structures and systems  January 2009, Hinxton, Cambridge, (poster P015)  [slideshare]

 

[48] Southan, C. (2008) The utility of new open-access resources for tracking down chemical structures of protein-protein  interaction inhibitors. 9th International Conference on Systems Biology Goteborg, Sweden, August 2008 [slideshare]

 

[47] Southan C (2006), The Devil is in the Annotation Details: Examples from Secreted Rat Ly-6 Proteins. In-Silico Analysis of Proteins Celebrating the 20th anniversary of Swiss-Prot,  Brazil, July 2006,  poster  RP118

 

[46] Southan C (2005), Not so many drug targets after all?  Reviewing the evidence for a low human protein-coding gene number. EBI Therapeutic Applications of Computational Biology, EBI, Hinxton UK, September, 2005 poster number 24

 

[45] Furnham, N, Ruffle S, & Southan C, (2003) Investigating alterantive splicing in proteases by comparative modelling of BACE1 splice variants. Biochemical Society  57th Harden Conference - Proteinase Structure and Function, Oriel College, Oxford, UK, September 2003, abstract no P008

 

[44] Hancock J & Southan, C (2003)  Tracing the evolutionary history of BACE1 and BACE2 Biochemical Society  57th Harden Conference - Proteinase Structure and Function, Oriel College, Oxford, UK, September 2003, abstract no P026.

 

[43]  Southan, C., (2000) Bioinformatic analysis of mRNA heterogenaity in the putative Alzheimers beta secretase, Asp2. (2000) Biochemical Society Meeting, Leeds, U.K. Biochem Soc. Trans. 28, (3) p84, abstract No. 63

 

[42] Christie, G.,  Powell D., Howlett, D.R., Tew, D.G., Meek ,T.D., Chapman, C., Gloger, I.S., Murphy, K.E,, Southan, C., Ryan, D.M., Smith, T.S., Simmons, D.L., Walsh, F.S., Dingwall, C., & Hussain I. (2000) Evaluation of two novel aspartic proteases as candidate beta-secretases. Forum of European Neuroscience, Brighton, U.K.

 

[41] Hussain I., Powell D., Howlett, D.R., Tew, D.G., Meek ,T.D., Chapman, C., Gloger, I.S., Murphy, K.E,, Southan, C., Ryan, D.M., Smith, T.S., Simmons, D.L., Walsh, F.S., Dingwall, C., & Christie, G (2000) Characterisation of two novel aspartic proteases as beta-secretases. World Alzheimer Congress, Washinton, USA.

 

[40] Southan, C. (1999) The vertebrate HtrA serine protease family: a new example of horizontal gene transfer. Biochemical Society Autumn Meeting Colloquium “Genomes; structure and function” Cork, Biochemical Society Transactions, 28, (1) pA40, abstract no.63.

 

[39] Southan, C. Schneider, K., Cutler, P., Birrell, H., Connelly, J. & Fantom, K. (1999) The analysis of rat nucleotide sequences related to a novel 2D-gel protein spot from rat urine identified by mass-spectrometry and protein sequencing. Association Of Biomolecular Resource Facilities Symposium, Durham, USA.

 

[38] Schneider, K., Southan, C., Birrell, H., Skehel, M, Connor, S., Connelly, J. & Cutler, P.,  (1999) Applications of mass-spectrometry in the identification of proteins from 1D and 2D gels. Applied Proteomics, IIR Biotechnology Conference, London, UK.

 

[37] Southan, C.,  (1998) The Platelet Activating Factor Acetylhydrolases: a New Lipase Family with Ancient Origins. 12th  Protein Society Symposium, San Diego, USA, Protein Science, 7, Suppl.1, p76, abstract no. 123.

 

[36] Southan, C.,  Tew D.G. &  Macphee C.H. (1997) Identification Of a Lipase via Expressed Sequence Tags: a New Enzyme Family And a New Strategy for  Protein Identification. Second European Protein Society Symposium, Cambridge UK, Protein Science, 6, Suppl.1, p70 abstract no. 153.

 

[35] Fantom, K.  Southan,C., Holder, J, Young P., & Pope A. (1997)  Multiple Identification Methodologies Applied to Thiazolidine Binding Proteins Located by 2-Dimensional Electrophoresis , European Protein Society Symposium, Cambridge UK, Protein Science, 6, Suppl.1,  p93 abstract no. 288)

 

[34] Southan, C. & Fantom, K. (1996) The Use of Chromatographic Packing for the Non-Covalent Immobilisation of Proteins and Peptides.  Ist Association Of Biomolecular Resource Facilities Symposium, San Fancisco USA.

 

[33] Southan, C. & Fantom, K.  (1995) Protein and peptide immobilisation on chromatographic packing for structural characterisation. , European Protein Society Symposium, Cambridge UK, Protein Science , 4  Suppl. 1,  p123  abstract no. 465

 

[32] Tew, D., Southan, C., Saul, H.F. & Macphee, C.H. (1995) Purification and sequencing of a novel LDL associated phospholipase which is involved in the oxidative modification of LDL. 64th Meeting of the  European Atherosclerosis Society, Utrecht, Atherosclerosis, 115 (Suppl.) S33.

 

[31] Macphee, C.H., Tew, D. G., Rice, S. Q. J., Lawrence, G. M. P, Southan C., Milliner, K. J ., Moores, K. E.,  Li  H . & Gloger, I.S., (1995) A novel phospholipase A2 has been cloned that is responsible for the increased  lyso-phosphatidylcholine content of oxidatively modified LDL. 64th Meeting of the  European Atherosclerosis Society, Utrecht, Atherosclerosis, 115 (suppl.)

 

[30] Lawrence, G.M.P, Rice, S.Q.J, Macphee, C.H, Southan, C.D, Li, H, Tew, D.G, Saul, H, Moores, K & Gloger, I.S.  (1995) Cloning and expression of a novel lipoprotein associated phospholipase A2. SB Genomic Symposium, Cambridge, UK.

 

[29] Southan, C. (1994) Rapid  and quantitative investigation of proteolysis using high-speed HPLC microcolumns. Journal Of Cellular Biochemistry, 18, p139

 

[28] Southan, C. (1993) High-speed peptide mapping and protein quantitation using Poros microcolumns.  VII th Symposium of the Protein Society , San Diego, USA, Protein Science , 2 (supplement),  p105

 

[27] Southan, C. & Lavery, P. (1993) Synergistic scale-down of three protein micropreparation techniques. 3rd  International Symposium on Protein Structure Function Relationships, Karachi, Pakistan.

 

[26] Southan, C. & Lavery, P. (1992) Optimised methods for enzyme micropurification. Structure & Activity of Enzymes, Royal Society of Chemistry Discussion Meeting,  Cambridge, U.K.

 

[25] Southan, C. & Lavery, P. (1992) Synergistic scale-down of three protein micropreparation techniques. IXth International Conference on Methods in Protein Sequence Analysis, Otsu, Japan.

 

[24] Southan, C., Leatherbarrow, R, & Wang, N  (1991) Origin of differences between 5 published sequences for dopamine beta-hydroxylase. Vth Symposium of The Protein Society, San Diego, U.S.A.,

 

[23] Southan, C., Okafo, G., Brown, R., & Camillari  P. (1991) Micro-preparative capillary electrophoresis for protein sequencing. Vth Symposium of The Protein Society, San Diego, U.S.A.,

 

[22] Southan, C., Saxty, B.A., & Wells, Tnc. (1990) The use of Phast gels for blotting and protein sequencing, Biochemical Society Spring Meeting, Bath, UK.

 

[21] Elshourbagy, N.E., Near, J., Wells, T.N.C.   , Southan, C., Groot, P.H.E. & Kmetz, P.J (1989) Cloning, sequencing, regulation and expression of rat and human ATP-citrate lyase. American Heart Association 62nd Scientific Session, New Orleans. USA, Circulation, 264(II), Abstract 1052.

 

[20] Southan, C. (1988) The use of glass capillary tubes as disposable microbore columns for RP-HPLC of proteins and peptides, Methods in Protein Sequence Analysis, Berlin.

 

[19] Brophy P.M. Barrett J & Southan C. (1988).  Glutathione S-transferase in Monezia Expansa (Cestoda), British Society for Parasitology Spring Meeting,  abstract  no. 159.

 

[18] Southan, C., Dewolfe W.E. And Kruse, L.I. (1988).  Bovine dopamine beta-hydroxylase:  extensive partial sequence data and characterisation of putative active site peptides labeled by mechanism based inhibitors.  2nd Symposium of The Protein Society, San Diego, U.S.A.

 

[17] Southan, C. (1987).  The measurement of plasma fibrinogen as a thrombotic risk factor:  a new HPLC based micro-assay able to detect increased fibrinogen synthesis .  Smith Kline & French Research Symposium on Hyperlipidaemia and Atherosclerosis, Cambridge, U.K.

 

[16] Southan, C. (1987).  Construction of a simple mini-column:  application to micro scale de-salting of peptides.  Ist Symposium of The Protein Society, San Diego, U.S.A., p46, abstract no. 819.

 

[15] Southan, C. (1987).  The use of the gas-phase sequencer for N-terminal determination.  Ist Symposium of The Protein Society, San Diego, U.S.A., p 54, abstract no. 1025.

 

[14] Southan, C. (1987).  The use of the gas-phase sequencer for multiple sequence assignments of a known protein.  Ist Symposium of The Protein Society, San Diego, U.S.A., p54, abstract no. 1024.

 

[13] Southan, C. & Aitken, A. (1986).  Application of the gas-phase sequencer for N-terminal determination.  VIth International Symposium on HPLC of Proteins, Peptides, and Polynucleotides, Baden-Baden, West Germany, p20, abstract no. 309.

 

[12] Southan, C., Thompson, E., & Lane, D.A. (1985).  Cleavage of the C-terminal polymerisation domain of fibrinogen by plasmin.  British Society for Thrombosis and Haemostasis, London.

 

[11] Southan, C, Thompson E, & Lane, D.A. (1985) The C-terminal polymerization domain of fibrinogen. Thrombosis and Haemostasis, 54, (1) p2

 

[10] Henschen, A., Kehl, M., Southan, C, & Lucas, J. (1984).  Influence of the amino acids surrounding the thrombin cleavage site on the cleavage of fibrinogen.  VIIIth International Congress on Thrombosis and Haemostasis, Istanbul, Turkey,  abstract no. 84.

 

[9] Southan, C., Thompson, E., & Lane, D.A. (1984).  Characterisation of peptides derived from the C-terminal polymerisation domain of fibrinogen.  VIIth International Congress on Thrombosis and Haemostasis, Istanbul, Turkey, abstract no. 80.

 

[8] Henschen, A., Kehl, M., & Southan, C. (1983).  Fibrinopeptide release in congenitally abnormal fibrinogens.  International Haematology Congress, Barcelona, Spain.

 

[7] Henschen, A, Kehl, M, &  Southan, C. (1983) Genetically abnormal fibrinogens: an overview of structurally elucidated variants. Thrombosis and Haemostasis,  50, (1) p416.

 

[6] Lane. D. A., Ireland, H., Thompson, E., Southan C., & Henschen, A. (1983) Fibrinogens  London-I-IV,  Manchester  and  Sydney-I, II: release of fibrinopeptides by  thrombin  and expression of their polymerization abnormalities. Thrombosis and Haemostasis, 50, (1)  p416.

 

[4] Southan, C., Lane, D.A., & Henschen, A. (1983)  Kinetic studies by  HPLC of fibrinopeptide release from fibrinogen Sydney I,  structural interpretation of the (His16) FPA cleavage rate and effects On FPB release. Thrombosis and Haemostasis, 50, (1) p336.

 

[3] Henschen, A., Southan, C., Kehl, M., & Bode, W. (1982) On the specificity of thrombin: evidence for the selective cleavage of a histidyl bond. Hoppe-Seylers Zeitschrift Fur-Physiologische-Chemie, 363,(9) p982.

 

[2] Henschen, A., Southan, C., Kehl, M.,  & Lottspeich, F. (1981) The  structural  error and its  relation to the malfunction in some abnormal fibrinogens. Thrombosis and Haemostasis, 46, (1) p181.

 

[1] Henschen, A., Southan, C., Soria. J., Soria C., &  Samama, M. (1981) Structure abnormality of Fibrinogen Metz and its relationship to the clotting defect.  Thrombosis and Haemostasis, 46, (1) p103.