Publications for Chris Southan
Sep 2011 (excluding patents). Top-five cited (from Google Scholar)
no [55] 774 citations, no. [67] 267, no. [58] 154, no. [4] ,
no. [52] 147.
ISI Articles with citation data = 30, citation
sum = 1877, average per-article = 62
h-index = 19. In SciFinder 92
articles and patents have 2219 citations
Open accesses for [79] = 5,396
*************************************
[85] Muresan, S, Petrov, P., Southan C., M. J. Kjellberg
M.J., Kogej. T., Tyrchan,
C., Varkonyi, P. Hongxing-Xie,
P. (20011) Making
every SAR point count: The development of Chemistry Connect for the large-scale
integration of structure and bioactivity data. Drug Discovery Today, accepted for publication.
[84] Orchard S et al. 18 authors including Southan C. (2011) Minimum Information About
a Bioactive Entity (MIABE). Nature Reviews in Drug Discovery, 10,
661-669
[83] Southan C, Sitzmann,
M, & Muresan, S. (2011) Mapping between databases of compounds and
protein targets. In: Bioinformatics and Drug Discovery (Methods in
Molecular Biology) ed. R S. Larson, Humana Press, in press.
[82*] Southan C, Boppana K , Jagarlapudi, SARP, & Muresan, S.
(2011) Analysis of in vitro bioactivity
data extracted from drug discovery literature and patents: Ranking 1654 human
protein targets by assayed compounds and molecular scaffolds. Journal of Cheminformatics, 3,
No. 14 (Open Access and Highly Accessed) PMID: 21569515
[81*] ,
Pascal Gaudet et
al. 36 authors including Southan C.
(2011), Towards BioDBcore:
a community-defined information specification for biological databases. Nucleic Acids Research, Vol. 39, No. suppl 1 (Annual database issue, 1 January 2011), pp. D7-D10
PMID: 21097465 (Open Access).
[80] Suriyawongkul, I., Southan, C., Várkonyi, P., & Muresan S. (2010) The Cinderella of Biological Data
Integration: Addressing the Challenges of Entity and Relationship Mining from Patent
Sources. In: Data Integration in the Life Sciences, Lecture Notes in Bioinformatics,
edited by: P. Lambrix and G. Kemp. Springer, Vol.
6254 (2010), pp. 106-121. [PDF]
[79*] Southan, C., Várkonyi,
P., & Muresan S. (2009) Quantitative assessment of the expanding complementarity between public
and commercial databases of bioactive compounds. Journal of Cheminformatics, Vol. 1, No. 1. 10 (Open Access and Highly Accessed) PMID: 20298516 [PDF]
[78] Southan C &
Cameron G. (2009) Beyond the
Tsunami: Developing the Infrastructure
to Deal with Life Science Data. In : Data
Intensive Computing: The Fourth Paradigm of Scientific Discovery, Eds T Hey and
[77*] Southan, C., Várkonyi, P., &
Muresan S. (2007) Complementarity between public and commercial databases:
new opportunities in medicinal chemistry informatics. Current Topics in Medicinal Chemistry, 7(15), 1502-8, PMID:
17897036 [PDF]
[76*] Southan, C. (2007) Exploiting new
genome data and web resources for the phylogenetic analyisis
of proteases, substrates and inhibitors. Biochemical Society Transactions,
35(3), 599-603, PMID:
17511660 [PDF]
[75] Southan, C. & Barnes M.R. (2007) Finding, Delineating and
Analysing Genes. In: Genetic
Bioinformatics: A Bioinformatics Guide for Geneticists, 2nd edition,
ed. M.R. Barnes, John Wiley & Son,
[74] Southan, C., Barnes M.R. & Ulvsbäck M. (2007) A
Bioinformatics Perspective on Genetics in Drug Discovery and Development. In: Genetic Bioinformatics: A Bioinformatics
Guide for Geneticists, 2nd edition, ed. M.R. Barnes, John Wiley
& Son,
[73*] Southan C. Has the Yo-yo stopped? a human gene number
update (2004) Proteomics 6
1712-26. PMID:
15174140 [PDF]
[72] McGowan, S et al. (84 authors)
including Southan, C. (2004) Annotation of the Human Genome by
High-Throughput Sequence Analysis of Naturally Occurring Proteins, Current Proteomics, 1,
41-48 [PDF]
[71*] Furnham N,
Ruffle S., & Southan C. (2004) Splice
variants: a homology modelling approach. Proteins: Stucture Function Genetics, 54(3):596-608, PMID:
14748006
[PDF]
[70] Southan, C (2003) Evolution of Human Proteases. In: Encyclopedia of the Human Genome, Nature
Publishing Group, Volume 4 pp 755-760 [PDF]
[69] Southan, C. (2003) Finding and analysing genes. In: Genetic
Bioinformatics: A Bioinformatics Guide for Geneticists, eds M.R. Barnes and Ian
C. Gray, John Wiley & Son,
[68] Barnes M.R. & Southan, C. (2003) Internet
resources for the geneticist. In:
Genetic Bioinformatics: A Bioinformatics Guide for Geneticists, eds M.R. Barnes
and I.C. Gray, John Wiley & Son,
[67*] Clausen,
T. Southan,
C. & Ehrmann, M. (2002) The HtrA Family of Proteases. Implications for Protein Composition and Cell Fate. Molecular
Cell, 10(3):443-455 PMID:
12408815 [PDF]
[66*] Rohlff, C. & Southan C
(2002) Proteomic
approaches to central nervous system disorders. Current Opinion in
Molecular Therapeutics, 4(3), 251-258 PMID:
12139311 [PDF]
[65*] Southan, C., Cutler, P., Birrell H., Connelly, J. Fantom K.G.M.,
Sims. M., Shaikh, N., & Schneider, K
(2002) The characterisation of novel secreted Ly-6 proteins from rat urine
by the combined use of 2-dimensional gel electrophoresis, microbore HPLC and
expressed sequence tag data. Proteomics, 2, 187-196 PMID:
11840564 [PDF]
[64*] Smith T.S, Southan C., Ellington K., Campbell D., David G. Tew D.G. &
Debouck, C. (2001) Identification, genomic organisation, and mRNA expression
of LACT-1, a mouse and human serine beta-lactamase-like gene with an N-terminal
transmembrane domain. Genomics, 78(1/2):12-14. PMID:
11707067 [PDF]
[63*] Southan C. (2001) A genomic perspective on human proteases as
drug targets.
Drug
Discovery Today. 6(13):681-688. PMID:
11427378 [PDF]
[62*] Southan C. (2001) A genomic perspective on human proteases.
FEBS Letters, 498(2-3), 214-218. PMID:
11412860 [PDF]
[61*] Southan
C. (2000) Website Review: InterPro the
integrated resource of protein functional domains. Yeast, 17, 327-334. PMID:
11119311 [PDF]
[59*] Southan, C. (2000) Assessing the protease and protease inhibitor
content of the human genome. Journal of Peptide Science, 6(9) 453-458. PMID:
11016882 [PDF]
[58*] Gray C.W., Ward, R.V., Karran E, Turconi, S.,
Rowles A., Viglienghi D., Southan
C., Barton A.A., West A.,
Savopoulos , J., Namir Hassan
N.J., Clinkenbeard H., Hanning C., Amegadzie B.,
Davis J.B., Dingwall C.,
Livi J.P, & Creasy C.L. (2000). Characterisation of human HtrA2, a novel serine protease involved in
the mammalian cellular stress response. European Journal of
Biochemistry, 267 (18), 5699 -5710. PMID:
10971580 [PDF]
[57*] Beeley L. J., Duckworth, M.
& Southan, C. (2000) The impact of
genomics on drug discovery. In: Progress
In Medicinal Chemistry-Vol 37, 1-43, (King F & Oxford A.W. eds)
Elsevier. PMID:
10845246
[56*] Smith T., & Southan, C (2000) Sequencing, tissue distribution and chromosomal
localisation of a novel ubiquitin-specific protease, UCP23. Biochimica et Biophysica Acta, 1490, 184-188. PMID:
10786635 [PDF]
[55*] Hussain I., Powell D., Howlett, D.R., Tew, D.G., Meek ,T.D.,
Chapman, C., Gloger, I.S., Murphy, K.E,, Southan,
C.D., Ryan, D.M., Smith, T.S., Simmons, D.L., Walsh, F.S., Dingwall, C., &
Christie, G (1999) Identification of a
novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci
14(6), 419-427. PMID:
10656250 [PDF]
[54*] Southan, C., Fantom, K, & Lavery,
P. (1999) Disposable microbore high pressure liquid
chromatography columns for protein and peptide separations. Analytical Biochemistry, 271, 152-158. PMID:
10419630 [PDF]
[53*] Rice S. Q., Southan,
C., Boyd, H.F., Terrett, J.A., Macphee, C.H., Moores, K., Gloger, I.S., &
Tew, D.G. (1998) Expression, purification and characterisation of a human serine
dependent phospholipase with high specificity for oxidised phospholipids and
platelet activating factor. Biochemical
Journal 330 (3) 1309-1315. PMID:
9494101 [PDF]
[52*] Tew D.T., Southan, C.,Rice S Q. J,
Lawrence M.P., Li, H., Gloger, I.S., Saul H.S. Moores, K & Macphee, C.H. (1996) Purification, properties,
sequencing and cloning of a lipoprotein
associated, serine-dependent phospholipase which is involved in the oxidative
modification of low density lipoproteins. Arteriosclerosis Thrombosis, Vascular Biology, 16 (4)
591-599. PMID:
8624782 [PDF]
[51] Southan,
C. (1996) Fast, flexible, sensitive, and
cheap: how to make your own high-speed microbore columns. ABRF News 7 (3)
18-21 [HTML
reprint]
[50] Southan,
C., Fantom, K, & Lavery, P. (1994) Fast,
flexible, sensitive, and cheap: the use of home-made microcolumns for the
separation of proteins and peptides. Journal of Protein Chemistry 13
(5) 461-462. (Short Communication)
[49] Southan,
C. (1992) The use of
chromatographic carbon as an inert support
for protein sequencing. In:
Techniques in protein chemistry III, (Hogue-Angeletti, R., ed) Academic Press,
[48*] Camilleri,
P., Okafo, G.N., Southan, C., &
Brown, R. (1991) Analytical and
micropreparative capillary electrophoresis of peptides from calcitonin. Analytical Biochemistry, 198,
(1) 36-42. PMID:
1665017 [PDF]
[47*] Camilleri, P., Okafo, G.N.,
& Southan, C. (1991) Separation by capillary electrophoresis
followed by dynamic elution. Analytical
Biochemistry, 196 (1), 178-182. PMID:
1888030 [PDF]
[46] Southan, C. (1990) Glass capillary microbore columns for protein and peptide separations.
Journal of Protein Chemistry 9
(3) 278-279. (Short Communication)
[45*] Wang, N., Southan, C., Dewolf,
W.E., Wells, T.N.C., Kruse, L.I. & Leatherbarrow, R.J. (1990) Bovine dopamine b-hydroxylase: primary structure determined
by c
[44*] Southan,
C., Dewolf, W.E. & Kruse, L.I.
(1990) Inactivation of dopamine b-hydroxylase
by r-cresol: evidence for a second,
minor site of covalent modification at tyrosine 357. Biochimica et
Biophysica Acta, 1037, 256-258. PMID:
2306476 [PDF]
[43*] Wilkinson, M.C., Cooper, D.P., Southan, C., Potter, P.M., & Margison-G.P.(1990)
Purification to apparent homogeneity and partial amino
acid sequence of rat-liver ortho-6-alkylguanine DNA alkyltransferase. Nucleic-Acids-Research, 18, (1)13-16.PMID:
2308819 [PDF]
[42*] Elshourbagy, N.E., Near, J., Kmetz, P.J.,
Sathe, G.E., Southan, C., Strickler,
J.E., Gross, M.S., Young, J.F., Groot, P.H.E. & Wells, T.N.C. (1990)
Rat ATP-citrate lyase: molecular
cloning and sequence analysis of a full-length cDNA and mRNA abundance as a
function of diet organ and age. Journal of Biological Chemistry, 265
(3), 1430-1435. PMID:
2295639 [PDF]
[41*] Southan, C. & Kruse, L.I. (1989)
Sequence similarity between
dopamine beta-hydroxylase and peptide a-amidating
enzyme: evidence for a conserved catalytic domain. FEBS
Letters 255 (1), 116-120.PMID:
2792366 [PDF]
[40*] Dewolf, W.E., Kruse, L.I.,
Chambers, P.A., Southan, C.,
Goodhart, P.J. & Saunders, D. (1989)
Inactivation of dopamine
beta-hydroxylase by beta-ethynyltyramine: kinetic characterisation and covalent
modification of an active site peptide. Biochemistry, 28 (9), 3833-3842.PMID:
2751998 [PDF]
[39] Southan, C. (1989) The use of glass
capillary tubes as microbore columns for HPLC of proteins and peptides. In:
Techniques in protein chemistry, (Hugli, T., ed)
Academic Press,
[38*] Brophy, P.M., Southan, C. & Barret, J. (1989) Glutathione
transferases in the tapeworm Moniezia
expansa. Biochemical Journal, 262,
939-946.PMID:
2590177
[37] Southan, C. (1988) The use of glass capillary tubes as
disposable microbore columns for RP-HPLC of proteins and peptides. Journal of Protein Chemistry 7
(3) 289-290. (Short Communication)
[36*] Dewolf, W.E., Carr, S.A.,
Varricho, A., Goodhart, P.J., Mentzer, M.A., Roberts, G.D., Southan, C., Dolle, R.E. & Kruse, L.I. (1988) Inactivation
of dopamine beta-hydroxylase by para-cresol: isolation and characterisation of
covalently modified active site peptides.
Biochemistry, 27 (26),
9093-9101. PMID:
3242615
[35*]
[34*] Knox, J.R.,
Boland, M.P., Freidlos, F., Coles, B., Southan,
C. & Roberts, J.J.
(1988) The nitroreductase in walker cells that activates 5-(aziridin-1-yl)2, 4-dinitrobenzamide to 5-(aziridin-1-yl) 2,4-hydroxylamino
-2- nitrobenzamide is a form of NAD(P)H dehydrogenase. Biochemical
Pharmacology, 37 (24), 4671-4677.PMID:
3144286
[33] Southan, C., (1988). Fibrinogen genetic disorders. In:
Fibrinogen, Fibrin Stabilisation and Fibrinolysis, (Francis, J. ed) Ellis Horwood,
[32] Southan, C., (1988). The elucidation of molecular
defects in congenital dysfibrinogenemia. In: Fibrinogen, Fibrin Stabilisation and
Fibrinolysis, (Francis, J. ed) Ellis Horwood,
[31] Fowler, L.J., Kennard, D.A.,
Kirby, N., Aitken, A. & Southan,
C. (1988) Studies
on liver GABA-transaminases.
In: Biochemistry of Vitamin B-6:
International Union of Biochemistry Symposium 166 (Korpela, T. & Christen,
P. eds) Birkhauser Verlag,
[30*] Southan, C., Aitken, A., Abbott, W.,
Childs, R. & Fezi, T. (1987).
The amino acid
sequence of bovine heart lectin, member of a novel protein family. FEBS letters, 214 (2),
301-304.PMID:
3569527 [PDF]
[29*] Ostlund Farrants, A.., Meyer, D.J., Coles, B, Southan, C., Aitken, A., Johnson P.J. & Ketterer, B. (1987)
The separation of glutathione transferase
subunits by using reverse-phase high-pressure liquid chromatography. Biochemical
Journal, 245, 423-428.PMID:
3663168
[28*] Southan, C., (1987). The use of sep-pak
cartridges for on-line high-performance liquid chromatography. Journal of Chromatography, 397,
395-404. PMID:
3654830
[27*] Southan, C., Thompson, E., & Lane, D.A., (1987). Direct
analysis of plasma fibrinogen - derived fibrinopeptides by high performance
liquid chromatography: Investigation of
nine congenital fibrinogen abnormalities.
British Journal of Haematology,
65, 469-473. PMID:
3580304
[26] Lane, D.A., & Southan, C. (1987). Inherited abnormalities of fibrinogen synthesis and structure. In:
Haemostasis and Thrombosis, 2nd edition, (Bloom, A.L., & Thomas,
D.P. eds.) Churchill Livingstone, Edinburgh, pp.
442-451.
[25] Lane, D.A., Thompson, E. & Southan, C. (1987)
Rapid screening method of
fibrinopeptide analysis applied to dysfibrinogenemia: summary of 23 cases In: Fibrinogen 2. Biochemistry, physiology and clinical
relevance (Low, G., Fores, C. & Douglas, J. eds.)
Elsevier Science Publishers B.V., Biomedical Division, pp. 71-74.
[24*] Southan, C., Thompson, E., & Lane,
D.A. (1986). Direct analysis of plasma fibrinogen-derived fibrinopeptides by high
performance liquid chromatography:
Investigation of A-alpha chain
N-terminal heterogeneity. Thrombosis and Haemostasis, 56,
193-197.PMID:
3643663
[23*] Southan, C., Thompson, E., & Lane,
D.A. (1986). Direct analysis of plasma
fibrinogen-derived fibrinopeptides by high performance liquid chromatography. Thrombosis
Research, 43, 195-204. PMID:
3738859
[22] Southan, C., Knight,
[21] Southan, C., Thompson, E. &
Lane, D.A. (1986). The C-terminal polymerisation domain of
fibrinogen. In Fibrinogen,
Fibrin Formation and Fibrinolysis, Volume 4, (Lane, D.A., Henschen, A., &
Jasani, M.K., eds)
Walter de Gruyter,
[20] Southan, C., Thompson, E. And Lane, D.A. (1986). Screening
small plasma samples by HPLC for abnormalities of fibrinopeptide release. In Fibrinogen, Fibrin Formation and
Fibrinolysis, Volume 4, (Lane, D.A., Henschen, A., & Jasani, M.K., eds) Walter de Gruyter,
[19] Southan, C. & Henschen, A. (1986). The analysis of Fibrinopeptide release from S-carboxymethylated
fibrinogen chains. In:
Fibrinogen: Structural Variants and Interactions, Volume 3, (Henschen, A.,
Hessel, B., McDonagh, J., & Saldeen, T. eds)
Walter
[18*] Southan, C., Thompson, E., Panico, M.,
Etienne, T., & Lane, D.A. (1985).
Characterisation
of peptides cleaved by plasmin from the C-terminal polymerisation domain of
fibrinogen. Journal of Biological Chemistry, 260
(24), 13095-13102.PMID:
2932434 [PDF]
[17*] Southan, C., Lane, D.A., Knight, I.,
Ireland, H., & Bottomly, J. (1985).
Fibrinogen
[16*] Southan, C., Lane, D.A., Bode, W., & Henschen, A. (1985). Thrombin
induced fibrinopeptide release from a fibrinogen variant (fibrinogen Sydney I) with an A-alpha 16 Arg -> His substitution. European
Journal of Biochemistry, 147, 593-600.PMID:
3979390
[15] Henschen, A., Kehl, M., & Southan, C., (1985). Genetically abnormal fibrinogens, strategies for structure elucidation
including fibrinopeptide analysis.
In: Variants of Human Fibrinogen,
(Beck, E.A., & Furlan, M., eds) Huber Verlag,
[14] Southan, C. (1984). Investigations on genetic
variants of fibrinogen. PhD Thesis, Ludwig-Maximillian University of Munich, Germany.
[13*] Henschen,
A., Kehl, M., & Southan, C.,
(1984). Genetically abnormal fibrinogens,
strategies for structure elucidation including fibrinopeptide analysis.
Current Problems In Clinical Biochemistry, 14,
273-320.PMID:
6391842
[12*] Southan, C., Kehl, M., Henschen, A.,
& Lane, D.A. (1983). Fibrinogen
[11*] Lane, D.A., Southan, C., Ireland, H., Thompson, E.,
Kehl, A. & Henschen, A.
(1983) Delayed release of an abnormal fibrinopeptide A from fibrinogen
[10] Southan, C., Lane, D.A., & Henschen, A. (1983). Functional
characterisation and protein chemical analysis of two new cases of dysfibrinogenemia,
London III and IV. In: Fibrinogen:
Structure - Functional Aspects - Metabolism, Volume 2, (Haverkate, F.,
Henschen, A., Nieuwenhuizen, W., & Straub, P.W. eds)
Walter
[*9] Henschen,
A., Lottspeich, F., Kehl, M., & Southan,
C. (1983). The covalent structure of human fibrinogen. In:
The Molecular Biology of Fibrinogen and Fibrin,
[8] Henschen, A., Kehl, M., Southan, C., Lottspeich, F. &
Dionysious,G. (1983).
Genetically
abnormal fibrinogens, some current characterisation strategies. In:
Fibrinogen: Structure - Functional Aspects - Metabolism, Volume 2,
(Haverkate, F., Henschen, A., Nieuwenhuizen, W., & Straub, P.W., eds) Walter
[7] Southan, C., Henschen, A., &
Lottspeich, F. (1982). The search for molecular defects in
abnormal fibrinogens.
In: Fibrinogen, Recent Biochemical and Medical Aspects, Volume 1
(Henschen, A., Graeff, H., & Lottspeich, F., eds)
Walter
[6] Henschen,
A., Lottspeich, F., Kehl, M., Southan,
C. & Lucas, J. (1982) Structure,
function, evolution, relationships
in fibrinogen.
In: Fibrinogen, Recent
Biochemical and Medical Aspects, Volume 1, (Henschen, A., Graeff, H. &
Lottspeich, F. eds) Walter
[5] Soria, J.,
Soria, S., Samama, M., Henschen, A. & Southan,
C. (1982) Detection
of the abnormality in dysfibrinogenemia: special report on Fibrinogen
[4] Henschen, A., Kehl, M., Southan, C. & Lottspeich, F. (1982) Structure
of normal and abnormal fibrinogens. In:
Verhandlung der Deutsch Geselshaft fur Innere Medicine, Volume 88, Bergeman,
Munchen, pp. 1261-1265.
[3] Henschen,
A., Kehl, M. & Southan, C. (1982)
Abnorme fibrinogene: beziehung
zwischen dysfunction und structurehler.
In: Haemostase, Thrombophilie und
Arteriosclerose, (Van de Loo, J. & Asbec, F. eds) Schattauer Verlag,
Stuttguart, pp. 661-664.
[2] Henschen,
A., Lottspeich, F., Kehl, M. & Southan,
C. (1981) Beziehung
zwischen structur, function und evolution im fibrinogen. In:
Microzirculation und Prostaglandin Stoffweschel. (Blumel, G. & Hass, S., eds) Schattauer
Verlag, Stuttguart, pp. 271-274.
[1] Henschen,
A., Lottspeich, F., Southan, C.
& Topfer-Peterson, E. (1980) Human
fibrinogen: sequence,
sulphur bridges, glycosylation and some structural variants. Proteins of the Biological Fluids,
Colloquium Proceedings 28, pp. 47-50.