Publications for Chris Southan
Total = 80 as of Aug 2010
(excluding abstracts and patents)
Breakdown: 45
journal papers (18 first-authored), 23 book articles or chapters, 7 reviews (2 first-authored)
and 4 short communications. The 45 entries marked with * have PubMed links.
Citations: top-five from Google Scholar, publication no [55] 617 citations, no.
[67] 191, no. [58] 130, no. [4] 110, no. [52] 108.
*************************************
[80]
Suriyawongkul,
[79]
Southan,
C., Várkonyi, P., & Muresan
S. (2009) Quantitative Assessment of the
Expanding Complementarity between Public and Commercial Databases of Bioactive
Compounds. Journal of Cheminformatics, [PDF]
[78] Southan C & Cameron G. (2009) Beyond the tsunami: Developing the
infrastructure to deal with life science data. In : Data
Intensive Computing: The Fourth Paradigm of Scientific Discovery, Eds T Hey and
[77*]
Southan,
C., Várkonyi, P., & Muresan S. (2007) Complementarity between public and
commercial databases: new opportunities in medicinal chemistry
informatics. Current Topics in
Medicinal Chemistry, 7(15),
1502-8, PMID:
17897036 [PDF]
[76*]
Southan, C. (2007)
Exploiting new Genome Data and Web Resources for the Phylogenetic Analyisis
of Proteases, Substrates and Inhibitors. Biochemical Society Transactions,
35(3), 599-603, PMID:
17511660 [PDF]
[75]
Southan, C. & Barnes M.R. (2007)
Finding, Delineating and Analysing Genes. In: Genetic Bioinformatics: A Bioinformatics
Guide for Geneticists, 2nd edition, ed. M.R. Barnes, John Wiley
& Son,
[74]
Southan, C., Barnes M.R. &
Ulvsbäck M. (2007) A Bioinformatics Perspective on Genetics in Drug
Discovery and Development. In:
Genetic Bioinformatics: A Bioinformatics Guide for Geneticists, 2nd
edition, ed. M.R. Barnes, John Wiley & Son,
[73*]
Southan C. Has
the Yo-yo stopped? a
human gene number update (2004) Proteomics
6 1712-26. PMID:
15174140 [PDF]
[72]
McGowan, S et al. (84 authors) including Southan,
C. (2004) Annotation of the Human Genome
by High-Throughput Sequence Analysis of Naturally Occurring Proteins, Current Proteomics, 1,
41-48 [PDF]
[71*] Furnham N, Ruffle S., & Southan C. (2004) Splice variants: a homology modelling approach. Proteins:
Stucture Function Genetics, 54(3):596-608, PMID:
14748006 [PDF]
[70]
Southan, C (2003) Evolution of
Human Proteases. In: Encyclopedia of
the Human Genome, Nature Publishing Group, Volume 4 pp 755-760 [PDF]
[69]
Southan, C. (2003) Finding and
analysing genes. In: Genetic Bioinformatics: A Bioinformatics Guide for
Geneticists, eds M.R. Barnes and Ian C. Gray, John Wiley & Son,
[68]
Barnes M.R. & Southan, C. (2003)
Internet resources for the geneticist.
In: Genetic Bioinformatics: A Bioinformatics Guide for Geneticists,
eds M.R. Barnes and I.C. Gray, John Wiley & Son,
[67*] Clausen, T. Southan,
C. & Ehrmann, M. (2002) The HtrA
Family of Proteases. Implications for Protein Composition and
Cell Fate. Molecular Cell, 10(3):443-455 PMID:
12408815 [PDF]
[66*]
Rohlff, C. & Southan C (2002) Proteomic approaches to
central nervous system disorders. Current Opinion in Molecular
Therapeutics, 4(3), 251-258 PMID:
12139311 [PDF]
[65*]
Southan, C., Cutler, P., Birrell H.,
Connelly, J. Fantom K.G.M., Sims. M.,
Shaikh, N., & Schneider, K (2002) The characterisation of novel
secreted Ly-6 proteins from rat urine by the combined use of 2-dimensional gel
electrophoresis, microbore HPLC and expressed sequence tag data. Proteomics,
2, 187-196 PMID:
11840564 [PDF]
[64*] Smith T.S, Southan C., Ellington K., Campbell D., David G. Tew D.G. & Debouck,
C. (2001) Identification, genomic organisation, and mRNA expression of
LACT-1, a mouse and human serine beta-lactamase-like gene with an N-terminal
transmembrane domain. Genomics, 78(1/2):12-14. PMID:
11707067 [PDF]
[63*] Southan C. (2001) A genomic perspective on human proteases as
drug targets.
Drug Discovery Today. 6(13):681-688. PMID:
11427378 [PDF]
[62*] Southan C. (2001) A genomic perspective on human proteases.
FEBS Letters, 498(2-3), 214-218. PMID:
11412860 [PDF]
[61*] Southan
C. (2000) Website Review: InterPro the
integrated resource of protein functional domains. Yeast, 17, 327-334. PMID:
11119311 [PDF]
[59*] Southan, C. (2000) Assessing the protease and protease inhibitor content of the human genome. Journal of Peptide Science, 6(9) 453-458. PMID:
11016882 [PDF]
[58*] Gray C.W., Ward, R.V., Karran E, Turconi, S.,
Rowles A., Viglienghi D., Southan
C., Barton A.A., West A.,
Savopoulos , J., Namir Hassan
N.J., Clinkenbeard H., Hanning C., Amegadzie B.,
Davis J.B., Dingwall C.,
Livi J.P, & Creasy C.L. (2000). Characterisation of human HtrA2, a novel serine protease involved in
the mammalian cellular stress response. European Journal of
Biochemistry, 267 (18), 5699 -5710. PMID:
10971580 [PDF]
[57*]
Beeley L. J., Duckworth, M. & Southan,
C. (2000) The
impact of genomics on drug discovery. In: Progress In Medicinal Chemistry-Vol 37, 1-43, (King F & Oxford A.W. eds)
Elsevier. PMID:
10845246
[56*] Smith T., & Southan, C (2000) Sequencing, tissue distribution and chromosomal
localisation of a novel ubiquitin-specific protease, UCP23. Biochimica et Biophysica Acta, 1490, 184-188. PMID:
10786635 [PDF]
[55*] Hussain I., Powell D., Howlett, D.R.,
Tew, D.G., Meek ,T.D., Chapman, C., Gloger, I.S., Murphy, K.E,, Southan, C.D., Ryan, D.M., Smith, T.S.,
Simmons, D.L., Walsh, F.S., Dingwall, C., & Christie, G (1999) Identification of a novel aspartic
protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14(6),
419-427. PMID:
10656250 [PDF]
[54*] Southan, C., Fantom, K, & Lavery, P. (1999) Disposable microbore high pressure liquid chromatography
columns for protein and peptide separations. Analytical Biochemistry, 271, 152-158. PMID:
10419630 [PDF]
[53*]
Rice S. Q., Southan, C., Boyd, H.F., Terrett, J.A., Macphee, C.H., Moores, K.,
Gloger, I.S., & Tew, D.G. (1998) Expression, purification and characterisation
of a human serine dependent phospholipase with high specificity for oxidised
phospholipids and platelet activating factor. Biochemical Journal 330 (3) 1309-1315. PMID:
9494101 [PDF]
[52*]
Tew D.T., Southan, C.,Rice S Q. J, Lawrence M.P., Li, H., Gloger, I.S.,
Saul H.S. Moores, K & Macphee, C.H. (1996) Purification, properties, sequencing and cloning of a lipoprotein associated, serine-dependent
phospholipase which is involved in the oxidative modification of low density
lipoproteins. Arteriosclerosis
Thrombosis, Vascular Biology, 16 (4) 591-599. PMID:
8624782 [PDF]
[51] Southan, C. (1996) Fast, flexible, sensitive, and cheap: how to
make your own high-speed microbore columns.
ABRF News 7 (3) 18-21 [HTML
reprint]
[50] Southan, C., Fantom, K, &
Lavery, P. (1994) Fast, flexible,
sensitive, and cheap: the use of home-made microcolumns for the separation of
proteins and peptides. Journal of Protein Chemistry 13
(5) 461-462. (Short Communication)
[49] Southan, C.
(1992) The use of chromatographic carbon as an inert support for protein sequencing. In:
Techniques in protein chemistry III, (Hogue-Angeletti, R., ed) Academic Press,
[48*]
Camilleri, P., Okafo, G.N., Southan, C., & Brown, R. (1991) Analytical and micropreparative capillary electrophoresis of peptides
from calcitonin. Analytical
Biochemistry, 198, (1) 36-42. PMID:
1665017 [PDF]
[47*]
Camilleri, P., Okafo, G.N., & Southan,
C. (1991) Separation by capillary
electrophoresis followed by dynamic elution. Analytical Biochemistry, 196 (1), 178-182. PMID:
1888030 [PDF]
[46] Southan, C. (1990) Glass capillary microbore columns for
protein and peptide separations. Journal
of Protein Chemistry 9 (3) 278-279. (Short Communication)
[45*]
Wang, N., Southan, C., Dewolf, W.E., Wells, T.N.C., Kruse, L.I. &
Leatherbarrow, R.J. (1990)
Bovine dopamine b-hydroxylase: primary structure determined by c
[44*] Southan,
C., Dewolf, W.E. & Kruse, L.I.
(1990) Inactivation of dopamine b-hydroxylase
by r-cresol: evidence for a second,
minor site of covalent modification at tyrosine 357. Biochimica et
Biophysica Acta, 1037, 256-258. PMID:
2306476 [PDF]
[43*] Wilkinson, M.C.,
Cooper, D.P., Southan, C., Potter,
P.M., & Margison-G.P.(1990) Purification to apparent
homogeneity and partial amino acid sequence of rat-liver ortho-6-alkylguanine
DNA alkyltransferase. Nucleic-Acids-Research, 18,
(1)13-16.PMID:
2308819 [PDF]
[42*] Elshourbagy, N.E., Near, J., Kmetz, P.J.,
Sathe, G.E., Southan, C., Strickler,
J.E., Gross, M.S., Young, J.F., Groot, P.H.E. & Wells, T.N.C. (1990)
Rat ATP-citrate lyase: molecular
cloning and sequence analysis of a full-length cDNA and mRNA abundance as a
function of diet organ and age. Journal of Biological Chemistry, 265
(3), 1430-1435. PMID:
2295639 [PDF]
[41*] Southan, C. & Kruse, L.I. (1989)
Sequence similarity between
dopamine beta-hydroxylase and peptide a-amidating
enzyme: evidence for a conserved catalytic domain. FEBS
Letters 255 (1), 116-120.PMID:
2792366 [PDF]
[40*]
Dewolf, W.E., Kruse, L.I., Chambers, P.A., Southan,
C., Goodhart, P.J. & Saunders, D. (1989)
Inactivation of dopamine
beta-hydroxylase by beta-ethynyltyramine: kinetic characterisation and covalent
modification of an active site peptide. Biochemistry, 28 (9), 3833-3842.PMID:
2751998 [PDF]
[39]
Southan, C. (1989)
The use of glass capillary tubes as microbore
columns for HPLC of proteins and peptides.
In: Techniques in protein
chemistry, (Hugli, T., ed) Academic Press,
[38*]
Brophy, P.M., Southan, C. &
Barret, J. (1989) Glutathione
transferases in the tapeworm Moniezia
expansa. Biochemical Journal, 262,
939-946.PMID:
2590177
[37] Southan, C. (1988) The use of glass
capillary tubes as disposable microbore columns for RP-HPLC of proteins and
peptides. Journal of Protein Chemistry 7 (3) 289-290. (Short Communication)
[36*]
Dewolf, W.E., Carr, S.A., Varricho, A., Goodhart, P.J., Mentzer, M.A., Roberts,
G.D., Southan, C., Dolle, R.E. &
Kruse, L.I.
(1988) Inactivation of dopamine beta-hydroxylase by para-cresol: isolation and
characterisation of covalently modified active site peptides. Biochemistry,
27 (26), 9093-9101. PMID:
3242615
[35*]
[34*]
Knox, J.R., Boland, M.P., Freidlos, F., Coles, B., Southan, C. & Roberts, J.J. (1988)
The nitroreductase in walker
cells that activates 5-(aziridin-1-yl)2,
4-dinitrobenzamide to 5-(aziridin-1-yl) 2,4-hydroxylamino -2- nitrobenzamide is
a form of NAD(P)H dehydrogenase. Biochemical Pharmacology, 37
(24), 4671-4677.PMID:
3144286
[33]
Southan, C., (1988). Fibrinogen genetic disorders. In: Fibrinogen, Fibrin
Stabilisation and Fibrinolysis, (Francis, J. ed) Ellis
Horwood,
[32]
Southan, C., (1988). The elucidation of molecular defects in congenital dysfibrinogenemia.
In: Fibrinogen, Fibrin Stabilisation and
Fibrinolysis, (Francis, J. ed) Ellis Horwood,
[31]
Fowler, L.J., Kennard, D.A., Kirby, N., Aitken, A. & Southan, C. (1988) Studies on liver GABA-transaminases. In:
Biochemistry of Vitamin B-6: International Union of Biochemistry
Symposium 166 (Korpela, T. & Christen, P. eds) Birkhauser Verlag,
[30*]
Southan, C.,
Aitken, A., Abbott, W., Childs, R. & Fezi, T. (1987). The amino acid sequence of bovine heart lectin, member of a novel
protein family. FEBS letters, 214 (2), 301-304.PMID:
3569527 [PDF]
[29*]
Ostlund Farrants, A.., Meyer, D.J., Coles, B, Southan, C., Aitken, A., Johnson P.J.
& Ketterer, B. (1987) The separation of
glutathione transferase subunits by using reverse-phase high-pressure liquid
chromatography. Biochemical Journal, 245,
423-428.PMID:
3663168
[28*]
Southan, C., (1987). The use of sep-pak cartridges for on-line high-performance liquid
chromatography. Journal of Chromatography, 397,
395-404. PMID:
3654830
[27*]
Southan, C., Thompson, E., &
Lane, D.A., (1987). Direct analysis of plasma fibrinogen - derived fibrinopeptides by high
performance liquid chromatography:
Investigation of nine congenital fibrinogen abnormalities. British
Journal of Haematology, 65, 469-473. PMID:
3580304
[26]
Lane, D.A., & Southan, C.
(1987). Inherited abnormalities of fibrinogen
synthesis and structure.
In: Haemostasis and Thrombosis,
2nd edition, (Bloom, A.L., & Thomas, D.P. eds.)
Churchill Livingstone, Edinburgh, pp. 442-451.
[25]
Lane, D.A., Thompson, E. & Southan,
C. (1987) Rapid
screening method of fibrinopeptide analysis applied to dysfibrinogenemia:
summary of 23 cases In: Fibrinogen 2. Biochemistry, physiology and clinical
relevance (Low, G., Fores, C. & Douglas, J. eds.) Elsevier
Science Publishers B.V., Biomedical Division, pp. 71-74.
[24*]
Southan, C.,
Thompson, E., & Lane, D.A. (1986).
Direct analysis of plasma
fibrinogen-derived fibrinopeptides by high performance liquid
chromatography: Investigation of A-alpha
chain N-terminal heterogeneity. Thrombosis
and Haemostasis, 56, 193-197.PMID:
3643663
[23*]
Southan, C.,
Thompson, E., & Lane, D.A. (1986).
Direct analysis
of plasma fibrinogen-derived fibrinopeptides by high performance liquid
chromatography. Thrombosis Research, 43, 195-204.
PMID:
3738859
[22]
Southan, C., Knight,
[21]
Southan, C., Thompson, E. &
Lane, D.A. (1986). The C-terminal polymerisation domain of
fibrinogen. In Fibrinogen,
Fibrin Formation and Fibrinolysis, Volume 4, (Lane, D.A., Henschen, A., & Jasani,
M.K., eds) Walter
de Gruyter,
[20]
Southan, C., Thompson, E. And Lane, D.A. (1986).
Screening small plasma samples by
HPLC for abnormalities of fibrinopeptide release. In Fibrinogen, Fibrin Formation and
Fibrinolysis, Volume 4, (Lane, D.A., Henschen, A., & Jasani, M.K., eds) Walter de Gruyter,
[19]
Southan, C. & Henschen, A.
(1986). The analysis of Fibrinopeptide release from
S-carboxymethylated fibrinogen chains. In: Fibrinogen: Structural Variants and
Interactions, Volume 3, (Henschen, A., Hessel, B., McDonagh, J., & Saldeen,
T. eds) Walter
[18*]
Southan, C.,
Thompson, E., Panico, M., Etienne, T., & Lane, D.A. (1985). Characterisation of peptides cleaved by plasmin from the C-terminal
polymerisation domain of fibrinogen.
Journal of Biological Chemistry,
260 (24), 13095-13102.PMID:
2932434 [PDF]
[17*]
Southan, C., Lane,
D.A., Knight,
[16*]
Southan, C., Lane, D.A., Bode, W.,
& Henschen, A. (1985). Thrombin induced fibrinopeptide release
from a fibrinogen variant (fibrinogen Sydney
I) with an A-alpha 16 Arg -> His substitution. European Journal of Biochemistry, 147,
593-600.PMID:
3979390
[15]
Henschen, A., Kehl, M., & Southan,
C., (1985). Genetically abnormal fibrinogens,
strategies for structure elucidation including fibrinopeptide analysis. In:
Variants of Human Fibrinogen, (Beck, E.A., & Furlan, M., eds) Huber Verlag,
[14]
Southan, C. (1984). Investigations on genetic variants of fibrinogen. PhD Thesis,
Ludwig-Maximillian University of Munich,
[13*]
Henschen, A., Kehl, M., & Southan, C., (1984). Genetically abnormal
fibrinogens, strategies for structure elucidation including fibrinopeptide
analysis. Current Problems In Clinical
Biochemistry, 14, 273-320.PMID:
6391842
[12*]
Southan, C., Kehl,
M., Henschen, A., & Lane, D.A. (1983). Fibrinogen
[11*]
Lane, D.A., Southan,
C.,
[10]
Southan, C., Lane, D.A., &
Henschen, A. (1983). Functional characterisation and protein
chemical analysis of two new cases of dysfibrinogenemia, London III and IV. In: Fibrinogen: Structure - Functional
Aspects - Metabolism, Volume 2, (Haverkate, F., Henschen, A.,
Nieuwenhuizen, W., & Straub, P.W. eds) Walter
[*9] Henschen, A., Lottspeich,
F., Kehl, M., & Southan, C.
(1983). The covalent structure of
human fibrinogen. In:
The Molecular Biology of Fibrinogen and Fibrin,
[8]
Henschen, A., Kehl, M., Southan, C.,
Lottspeich, F. & Dionysious,G. (1983). Genetically abnormal fibrinogens, some current characterisation
strategies. In: Fibrinogen: Structure - Functional Aspects -
Metabolism, Volume 2, (Haverkate, F., Henschen, A., Nieuwenhuizen, W., &
Straub, P.W., eds) Walter
[7] Southan, C., Henschen, A., & Lottspeich, F. (1982). The search for molecular defects in abnormal
fibrinogens. In: Fibrinogen, Recent Biochemical and
Medical Aspects, Volume 1 (Henschen, A., Graeff, H., & Lottspeich, F., eds) Walter
[6] Henschen, A., Lottspeich,
F., Kehl, M., Southan, C. &
Lucas, J. (1982) Structure, function, evolution,
relationships in fibrinogen. In:
Fibrinogen, Recent Biochemical and Medical Aspects, Volume 1, (Henschen,
A., Graeff, H. & Lottspeich, F. eds) Walter
[5] Soria, J., Soria, S.,
Samama, M., Henschen, A. & Southan,
C. (1982) Detection
of the abnormality in dysfibrinogenemia: special report on Fibrinogen
[4] Henschen, A., Kehl, M., Southan, C. & Lottspeich, F. (1982) Structure
of normal and abnormal fibrinogens. In:
Verhandlung der Deutsch Geselshaft fur Innere Medicine, Volume 88, Bergeman,
Munchen, pp. 1261-1265.
[3] Henschen, A., Kehl, M.
& Southan, C. (1982)
Abnorme fibrinogene: beziehung
zwischen dysfunction und structurehler.
In: Haemostase, Thrombophilie und
Arteriosclerose, (Van de Loo, J. & Asbec, F. eds) Schattauer Verlag,
Stuttguart, pp. 661-664.
[2] Henschen, A., Lottspeich,
F., Kehl, M. & Southan, C. (1981)
Beziehung zwischen structur,
function und evolution im fibrinogen.
In: Microzirculation und
Prostaglandin Stoffweschel. (Blumel, G.
& Hass, S., eds) Schattauer Verlag, Stuttguart, pp. 271-274.
[1] Henschen, A., Lottspeich,
F., Southan, C. &
Topfer-Peterson, E. (1980) Human fibrinogen: sequence, sulphur bridges, glycosylation and
some structural variants. Proteins
of the Biological Fluids, Colloquium Proceedings 28, pp. 47-50.